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If you have surgery or a medical emergency. Prednisolone is a corticosteroid medicine. Prednisone and Prednisolone are considered to be intermediate acting steroids, meaning that a dose lasts about a day or a day and a half. Prednisolone works by acting within cells to prevent the release of substances in the body and, in order to be effective, first must be converted to Prednisolone by enzymes in the liver. Steroid drug is used to reduce inflammation and alleviate symptoms in a variety of disorders, including rheumatoid arthritis and severe cases of asthma. Prednisolone prevents the release of substances in the body that cause inflammation. Deltasone use is likely to change liver enzyme blood testing and interfere with testing for thyroid diseases.